‘Corrective glass’ for mass spectrometry imaging

The chemical analysis of biological tissues with three-dimensional shapes has been a major problem so far. Researchers at the Max Planck Institute for Chemical Ecology in Jena, Germany, have now improved mass spectrometry imaging in such a way that the distribution of molecules can also be visualized on rippled, hairy, bulgy or coarse surfaces. The source of the laser-based technique was custom-built to accommodate the topography of non-flat samples. By employing a distances sensor, a height profile of the surface is recorded before the actual chemical imaging. The new tool can be used for answering ecological questions from a new perspective.