At first glance, the yeast Candida krusei seems as innocuous as microbes come: it’s used for fermenting cocoa beans and gives chocolate its pleasant aroma. But it’s increasingly found as a pathogen in immunocompromised patients—and C. krusei infections aren’t always easy to cure. This yeast is naturally resistant to fluconazole, a first-line antifungal that’s vital not just for treating many fungal infections but also for preventing them in susceptible populations. In the September issue of G3, Cuomo et al. unveil the first whole-genome sequence of a clinical sample of C. krusei, providing leads on genes that may be important for the species’ fluconazole resistance.