A team of researchers with members from Harvard University and one from the University of California San Diego has carried out experiments with yeast that show more-fit lineages are less tolerant to deleterious mutations than are those that are less fit. In their paper published in the journal Science, the group describes forcing a number of mutations into the backgrounds of yeast and what they learned about evolutionary fitness by doing so. Craig Miller with the University of Idaho has published an accompanying Perspectives piece in the same journal issue discussing the work by the team.
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Source: Phys.org