Researchers at the Rudolf Virchow Center of the University of Würzburg have unveiled the crystal structures of UBA6 in complex with either ATP or the ubiquitin-like protein FAT10. These results provide the foundation to study the individual roles of UBA6 towards the attachment of either ubiquitin or FAT10 to target proteins and the downstream cellular pathways with possible implications for the etiology of certain tumors. This study was published in the journal Nature Communications.
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Source: Phys.org