(Phys.org)\u2014Researchers from McGill University in Montreal have devised a novel carbon-carbon bond-forming reaction that serves as an alternative to a nucleophilic addition reaction of an organometallic compound to a carbonyl (e.g., Grignard reaction). Common aldehydes, when reacted with hydrazine to form hydrazones, are then activated with a ruthenium-based catalyst and serve as the nucleophilic carbanions that attack an electrophilic carbonyl, forming secondary or tertiary alcohols. This alternative reaction demonstrated both selectivity and versatility in a variety of carbonyl compounds, including those that would serve as naturally-occurring feedstocks. Their work appears in Nature Chemistry.<\/p>\n","protected":false},"excerpt":{"rendered":"
(Phys.org)—Researchers from McGill University in Montreal have devised a novel carbon-carbon bond-forming reaction that serves as an alternative to a nucleophilic addition reaction of an organometallic compound to a carbonyl (e.g., Grignard reaction). Common aldehydes, when reacted with hydrazine to form hydrazones, are then activated with a ruthenium-based catalyst and serve as the nucleophilic carbanions that attack an electrophilic carbonyl, forming secondary or tertiary alcohols. This alternative reaction demonstrated both selectivity and versatility in a variety of carbonyl compounds, including those that would serve as naturally-occurring feedstocks. Their work appears in Nature Chemistry.<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-255814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/255814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=255814"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/255814\/revisions"}],"predecessor-version":[{"id":255815,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/255814\/revisions\/255815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=255814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=255814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=255814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}