{"id":286760,"date":"2017-03-13T13:50:01","date_gmt":"2017-03-13T17:50:01","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/03\/170313135001.htm"},"modified":"2017-03-13T13:50:01","modified_gmt":"2017-03-13T17:50:01","slug":"a-multidrug-efflux-pump-in-motion-2","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=286760","title":{"rendered":"A multidrug efflux pump in motion"},"content":{"rendered":"<p>Researchers have mapped the conformational changes that occur in a protein &#8216;notorious&#8217; for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system. Their report is an important step forward in understanding &#8211; and perhaps one day interfering with &#8211; the highly dynamic ABC transporter known as P-glycoprotein. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have mapped the conformational changes that occur in a protein &#8216;notorious&#8217; for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system. Their report is an important step forward i&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-286760","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/286760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=286760"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/286760\/revisions"}],"predecessor-version":[{"id":286761,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/286760\/revisions\/286761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=286760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=286760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=286760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}