{"id":298284,"date":"2017-04-07T07:49:06","date_gmt":"2017-04-07T11:49:06","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=1beb38083f69fffe83997c718a6c95f9"},"modified":"2017-04-07T07:49:06","modified_gmt":"2017-04-07T11:49:06","slug":"pinpoint-creation-of-chirality-by-organic-catalysts","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=298284","title":{"rendered":"Pinpoint creation of chirality by organic catalysts"},"content":{"rendered":"<p>Researchers at Nagoya University have reported in Nature Communications on the development of an organic catalyst (organocatalyst) that triggers a highly stereoselective 1,6-addition of azlactones (nucleophile) to a \u03b4-aryl dienyl carbonyl compound (electrophile) to generate amino acid derivatives in high yields. The generated 1,6-adduct contains two carbon stereocenters, and a slight structural change in the organocatalyst leads to inversion of stereochemistry at a single stereocenter to form a diastereomer in high selectivity. The group started this research in 2012 and found this inversion of stereochemistry upon screening various amino acids incorporated in their unique iminophosphorane catalyst.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Nagoya University have reported in Nature Communications on the development of an organic catalyst (organocatalyst) that triggers a highly stereoselective 1,6-addition of azlactones (nucleophile) to a &delta;-aryl dienyl carbonyl compound (electrophile) to generate amino acid derivatives in high yields. The generated 1,6-adduct contains two carbon stereocenters, and a slight structural change in the organocatalyst leads to inversion of stereochemistry at a single stereocenter to form a diastereomer in high selectivity. The group started this research in 2012 and found this inversion of stereochemistry upon screening various amino acids incorporated in their unique iminophosphorane catalyst.<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-298284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/298284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=298284"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/298284\/revisions"}],"predecessor-version":[{"id":298285,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/298284\/revisions\/298285"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=298284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=298284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=298284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}