{"id":337743,"date":"2017-06-29T12:00:08","date_gmt":"2017-06-29T16:00:08","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=ebcbd74fd54a26b0c9eac5303aa38f6c"},"modified":"2017-06-29T12:00:08","modified_gmt":"2017-06-29T16:00:08","slug":"a-new-ribosomal-biogenesis-regulation-point-to-treat-cancer-and-5q-syndrome","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=337743","title":{"rendered":"A new ribosomal biogenesis regulation point to treat cancer and 5q- syndrome"},"content":{"rendered":"<p>Researchers at the Catalan Institute of Oncology have discovered a new role for free 40S ribosomes as guardians of genetic information required to synthesize themselves. This mechanism, which relies on a complex of free 40S ribosomes and the RNA binding protein LARP1, is independent from the 40S ribosomes role in protein synthesis, which can be potentially targeted as a cancer therapy. Moreover, together with researchers at the IDIBAPS, Barcelona, they also found that the 40S-LARP1 complex may be a potential point of intervention for the treatment of 5q- syndrome, a rare sporadic genetic disease, which they demonstrate is causally linked to the loss of LARP1 and free 40S ribosomes<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the Catalan Institute of Oncology have discovered a new role for free 40S ribosomes as guardians of genetic information required to synthesize themselves. This mechanism, which relies on a complex of free 40S ribosomes and the RNA bindin&#8230;<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-337743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/337743","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=337743"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/337743\/revisions"}],"predecessor-version":[{"id":337744,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/337743\/revisions\/337744"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=337743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=337743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=337743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}