{"id":338223,"date":"2017-06-30T07:33:10","date_gmt":"2017-06-30T11:33:10","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=d4d58aa1f9b898ae76e999c60fa79842"},"modified":"2017-06-30T07:33:10","modified_gmt":"2017-06-30T11:33:10","slug":"preserving-the-active-chromatin-state","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=338223","title":{"rendered":"Preserving the active chromatin state"},"content":{"rendered":"<p>If cellular identity is to be maintained, it is important that actively transcribed chromatin stretches remain in a loose configuration as long as these genes are needed. Marc B\u00fchler and his group have uncovered a novel positive feedback loop \u2013 crucially involving the histone acetyltransferase Mst2 \u2013 which ensures that (transcriptionally active) euchromatin cannot be easily converted into (inactive) heterochromatin. Because some of the players in this feedback loop have been implicated in cancer, these findings are relevant to our understanding of human diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If cellular identity is to be maintained, it is important that actively transcribed chromatin stretches remain in a loose configuration as long as these genes are needed. Marc B&uuml;hler and his group have uncovered a novel positive feedback loop &ndash; crucially involving the histone acetyltransferase Mst2 &ndash; which ensures that (transcriptionally active) euchromatin cannot be easily converted into (inactive) heterochromatin. Because some of the players in this feedback loop have been implicated in cancer, these findings are relevant to our understanding of human diseases.<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-338223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/338223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=338223"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/338223\/revisions"}],"predecessor-version":[{"id":338224,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/338223\/revisions\/338224"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=338223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=338223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=338223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}