{"id":339390,"date":"2017-07-03T17:04:50","date_gmt":"2017-07-03T21:04:50","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/07\/170703170450.htm"},"modified":"2017-07-03T17:04:50","modified_gmt":"2017-07-03T21:04:50","slug":"freeze-frames-of-enzymes-in-action-have-implications-for-a-new-cancer-treatment-concept","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=339390","title":{"rendered":"Freeze-frames of enzymes in action have implications for a new cancer treatment concept"},"content":{"rendered":"<p>Structural biologists shed light on how a family of enzymes called TUTases regulate let-7, an essential regulator of development that is dyregulated in lung and kidney cancers, among others. The team used x-ray crystallography to capture the equivalent of freeze-frames of TUTases, at the resolution of individual atoms, interacting with other molecules to regulate the activity of let-7. this work will aid efforts to target TUTases as a way of increasing expression of let-7 in cancer cells. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Structural biologists shed light on how a family of enzymes called TUTases regulate let-7, an essential regulator of development that is dyregulated in lung and kidney cancers, among others. The team used x-ray crystallography to capture the equivalent&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-339390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/339390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=339390"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/339390\/revisions"}],"predecessor-version":[{"id":339391,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/339390\/revisions\/339391"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=339390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=339390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=339390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}