{"id":340032,"date":"2017-07-05T09:53:30","date_gmt":"2017-07-05T13:53:30","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/07\/170705095330.htm"},"modified":"2017-07-05T09:53:30","modified_gmt":"2017-07-05T13:53:30","slug":"small-molecule-therapeutic-boosts-spatial-memory-and-motor-function-in-rett-syndrome-mice","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=340032","title":{"rendered":"Small-molecule therapeutic boosts spatial memory and motor function in Rett syndrome mice"},"content":{"rendered":"<p>Rett syndrome is a neurological disorder affecting learning and development, caused by a mutation in the MECP2 gene triggering decreased levels of brain-derived neurotrophic factor (BDNF). Previous research has shown that treatment with a small-molecule BDNF mimetic, LM22A-4, can lead to improvements in respiratory problems associated with the disease. Now, new research reveals that LM22A-4 may also improve spatial memory and motor skill defects in a Rett syndrome mouse model. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rett syndrome is a neurological disorder affecting learning and development, caused by a mutation in the MECP2 gene triggering decreased levels of brain-derived neurotrophic factor (BDNF). Previous research has shown that treatment with a small-molecul&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-340032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/340032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=340032"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/340032\/revisions"}],"predecessor-version":[{"id":340033,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/340032\/revisions\/340033"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=340032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=340032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=340032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}