Rodent Research-5 (RR-5) Systemic Therapy of NELL-1 for Osteoporosis:\u00a0 The crew completed injections of half of the RR-5 mice remaining on the ISS in the Microgravity Science Glovebox (MSG) and performed bone densitometer scans of each of those mice. Because spaceflight has significant and rapid effects on the musculoskeletal system it is important to investigate targeted therapies that could ameliorate some of the detrimental effects of spaceflight. The NELL-1 drug being studied in the RR-5 investigation has the potential to slow or reverse bone loss during spaceflight.The Bone Densitometer device measures the density of minerals in bone. Quantitative measures of bone loss in mice during orbital space flight provide data for the development of countermeasures for human crewmembers, as well as for bone-loss syndromes on Earth.\u00a0 S-Band String 2 Space to Ground (S\/G)-2 Audio Troubleshooting: Ground teams performed troubleshooting steps for distorted S\/G-2 downlink voice experienced while on S-Band String 2. The distortion was first observed last Wednesday, June 28th.\u00a0 Since then, ground teams performed various troubleshooting steps to isolate the problem to String 2 of the S-Band System. Today\u2019s troubleshooting focused on the S-Band Baseband Signal Processor (BSP)-2.\u00a0 BSP-2 built in tests were executed without errors followed by a power cycle of the unit and a repeat of S\/G-2 communication checks. The distortion was no longer present after the power cycle.\u00a0 S-Band String 2 remains the active string.\u00a0\u00a0\u00a0\u00a0\u00a0 Today\u2019s Planned Activities All activities were completed unless otherwise noted. 50S Samsung Tablet Battery Status Check and Recharge (if it is less than 80% charged) Nikon Camera Time Synch with Station Time Test Video Recording for Russia Today TV Channel VIZIR. SM Panels 114 and 116 Outfitting for C\u041a\u041f\u0424-\u0423\u041c Payload Preparation of Reports for Roscosmos Web Site and Social Media \u0420\u0421\u041f\u0418. Deletion of Files from Onboard Memory Device (\u0411\u0417\u0423) ECON-M. Observation and Photography Combustion Integrated Rack Alignment Guide Removal RADIOSCAF. \u0422\u0430\u043d\u044e\u0448\u0430-\u042e\u0417\u0413\u0423-1 Nanosatellite Deactivation Regeneration of Micropurification Unit (\u0411\u041c\u041f) Cartridge \u04242 (start) Water Transfer from Progress 67P (SM Aft) Rodnik Water Tank \u0411\u04122 into SM Rodnik Water Tank \u0411\u04122 Water Conditioning Unit (\u0411\u041a\u0412) Purification Column (\u0411\u041a) and [C\u0420\u0412\u041a-2\u041c] Hoses R&R Countermeasures System (CMS) Heart Rate Monitor (HRM) iPad Downlink Water Conditioning Unit (\u0411\u041a\u0412) Purification Column (\u0411\u041a) and [C\u0420\u0412\u041a-2\u041c] Hoses R&R Rodent Research Node 2 Camcorder Video Setup Rodent Research Injection and Bone Densitometer 1B Rodent Research MELFI Retrieve 4 Rodent Research MELFI Retrieve 6 Rodent Research Injection and Bone Densitometer 1A Central Post Laptop Monthly Routine Maintenance Copying of Log Files from Central Post Laptop after Monthly Routine Maintenance Rodent Research Bone Densitometer Scans Progress 67P (SM Aft) Water Tank Bladder Compression Rodent Research Injection and Bone Densitometer 1B Water Conditioning Unit (\u0411\u041a\u0412) Purification Column (\u0411\u041a) and [C\u0420\u0412\u041a-2\u041c] Hoses R&R Rodent Research Injection and Bone Densitometer 1B Rodent Research MELFI Retrieve 6 Rodent Research Injection and Bone Densitometer 2A [\u0421\u0420\u0412\u041a-2\u041c] Water Conditioning Unit (\u0411\u041a\u0412) Flush (start) Rodent Research Bone Densitometer Stow Rodent Research Injection and Bone Densitometer 1B Reconfigure LAB camcorder and Dual Canon Li-Ion Battery Charger to nominal config Progress 67P (SM Aft) Water Tank Bladder Compression \u2013 Closeout Operations Atmosphere Control and Supply (ACS) Nitrogen Manual Valve Open RADIOSCAF. \u0422\u0430\u043d\u044e\u0448\u0430-\u042e\u0417\u0413\u0423-1 Nanosatellite Activation Regeneration of Micropurification Unit (\u0411\u041c\u041f) Cartridge \u04242 Completed Task List Items Photos of the EMCS HV20 Handle, the valve, and surrounding area Ground Activities All activities were completed unless otherwise noted. Rodent Research ops support S-Band String 2 S\/G2 audio troubleshooting Three-Day Look Ahead: Thursday, 07\/06: MSPR Group Combustion closeout, PWD water collect, JEM Camera Robot ops Friday, 07\/07: Fluid Shifts, JSSOD sat deploy, Meteor hard drive swap Saturday, 07\/08: Crew off duty, housekeeping QUICK ISS Status \u2013 Environmental Control Group: \u00a0\u00a0Component Status Elektron Off Vozdukh Manual [\u0421\u041a\u0412] 1 \u2013 SM Air Conditioner System (\u201cSKV1\u201d) Off\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 [\u0421\u041a\u0412] 2 \u2013 SM Air Conditioner System (\u201cSKV2\u201d) On Carbon Dioxide Removal Assembly (CDRA) Lab Standby Carbon Dioxide Removal Assembly (CDRA) Node 3 Operate Major Constituent Analyzer (MCA) Lab Idle Major Constituent Analyzer (MCA) Node 3 Operate Oxygen Generation Assembly (OGA) Process Urine Processing Assembly (UPA) Process Trace Contaminant Control System (TCCS) Lab Full up Trace Contaminant Control System (TCCS) Node 3 Off \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
Rodent Research-5 (RR-5) Systemic Therapy of NELL-1 for Osteoporosis: The crew completed injections of half of the RR-5 mice remaining on the ISS in the Microgravity Science Glovebox (MSG) and performed bone densitometer scans of each of those mice. Because spaceflight has significant and rapid effects on the musculoskeletal system it is important to investigate targeted therapies that could ameliorate some of the detrimental effects of spaceflight. The NELL-1 drug being studied in the RR-5 investigation has the potential to slow or reverse bone loss during spaceflight.The Bone Densitometer device measures the density of minerals in bone. Quantitative measures of bone loss in mice during orbital space flight provide data for the development of countermeasures for human crewmembers, as well as for bone-loss syndromes on Earth. S-Band String 2 Space to Ground (S\/G)-2 Audio Troubleshooting: Ground teams performed troubleshooting steps for distorted S\/G-2 downlink voice experienced while on S-Band String 2. The distortion was first observed last Wednesday, June 28th. Since then, ground teams performed various troubleshooting steps to isolate the problem to String 2 of the S-Band System. Today’s troubleshooting focused on the S-Band Baseband Signal Processor (BSP)-2. BSP-2 built in tests were executed without errors followed by a power cycle of the unit and a repeat of S\/G-2 communication checks. The distortion was no longer present after the power cycle. S-Band String 2 remains the active string. Today’s Planned Activities All activities were completed unless otherwise noted. 50S Samsung Tablet Battery Status Check and Recharge (if it is less than 80% charged) Nikon Camera Time Synch with Station Time Test Video Recording for Russia Today TV Channel VIZIR. SM Panels 114 and 116 Outfitting for CКПФ-УМ Payload Preparation of Reports for Roscosmos Web Site and Social Media РСПИ. Deletion of Files from Onboard Memory Device (БЗУ) ECON-M. Observation and Photography Combustion Integrated Rack Alignment Guide Removal RADIOSCAF. Танюша-ЮЗГУ-1 Nanosatellite Deactivation Regeneration of Micropurification Unit (БМП) Cartridge Ф2 (start) Water Transfer from Progress 67P (SM Aft) Rodnik Water Tank БВ2 into SM Rodnik Water Tank БВ2 Water Conditioning Unit (БКВ) Purification Column (БК) and [CРВК-2М] Hoses R&R Countermeasures System (CMS) Heart Rate Monitor (HRM) iPad Downlink Water Conditioning Unit (БКВ) Purification Column (БК) and [CРВК-2М] Hoses R&R Rodent Research Node 2 Camcorder Video Setup Rodent Research Injection and Bone Densitometer 1B Rodent Research MELFI Retrieve 4 Rodent Research MELFI Retrieve 6 Rodent Research Injection and Bone Densitometer 1A Central Post Laptop Monthly Routine Maintenance Copying of Log Files from Central Post Laptop after Monthly Routine Maintenance Rodent Research Bone Densitometer Scans Progress 67P (SM Aft) Water Tank Bladder Compression Rodent Research Injection and Bone Densitometer 1B Water Conditioning Unit (БКВ) Purification Column (БК) and [CРВК-2М] Hoses R&R Rodent Research Injection and Bone Densitometer 1B Rodent Research MELFI Retrieve 6 Rodent Research Injection and Bone Densitometer 2A [СРВК-2М] Water Conditioning Unit (БКВ) Flush (start) Rodent Research Bone Densitometer Stow Rodent Research Injection and Bone Densitometer 1B Reconfigure LAB camcorder and Dual Canon Li-Ion Battery Charger to nominal config Progress 67P (SM Aft) Water Tank Bladder Compression – Closeout Operations Atmosphere Control and Supply (ACS) Nitrogen Manual Valve Open RADIOSCAF. Танюша-ЮЗГУ-1 Nanosatellite Activation Regeneration of Micropurification Unit (БМП) Cartridge Ф2 Completed Task List Items Photos of the EMCS HV20 Handle, the valve, and surrounding area Ground Activities All activities were completed unless otherwise noted. Rodent Research ops support S-Band String 2 S\/G2 audio troubleshooting Three-Day Look Ahead: Thursday, 07\/06: MSPR Group Combustion closeout, PWD water collect, JEM Camera Robot ops Friday, 07\/07: Fluid Shifts, JSSOD sat deploy, Meteor hard drive swap Saturday, 07\/08: Crew off duty, housekeeping QUICK ISS Status – Environmental Control Group: Component Status Elektron Off Vozdukh Manual [СКВ] 1 – SM Air Conditioner System (“SKV1”) Off [СКВ] 2 – SM Air Conditioner System (“SKV2”) On Carbon Dioxide Removal Assembly (CDRA) Lab Standby Carbon Dioxide Removal Assembly (CDRA) Node 3 Operate Major Constituent Analyzer (MCA) Lab Idle Major Constituent Analyzer (MCA) Node 3 Operate Oxygen Generation Assembly (OGA) Process Urine Processing Assembly (UPA) Process Trace Contaminant Control System (TCCS) Lab Full up Trace Contaminant Control System (TCCS) Node 3 Off <\/p>\n","protected":false},"author":59,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-340717","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/340717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=340717"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/340717\/revisions"}],"predecessor-version":[{"id":340718,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/340717\/revisions\/340718"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=340717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=340717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=340717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}