{"id":353408,"date":"2017-08-02T13:47:54","date_gmt":"2017-08-02T17:47:54","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/08\/170802134754.htm"},"modified":"2017-08-02T13:47:54","modified_gmt":"2017-08-02T17:47:54","slug":"a-braf-kinase-inactive-mutant-induces-lung-adenocarcinoma","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=353408","title":{"rendered":"A Braf kinase-inactive mutant induces lung adenocarcinoma"},"content":{"rendered":"<p>The initiating oncogenic event in half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies. Researchers have demonstrated that the expression of an endogenous Braf kinase-inactive isoform in mice triggers lung adenocarcinoma in vivo, indicating that BRAF-inactivating mutations are initiating events in lung oncogenesis. The paper indicates that the signal intensity of the MAPK pathway is a critical determinant in tumor development. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>The initiating oncogenic event in half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies. Researchers have demonstrated that the expression of an endogenous Braf kinase-inactive isof&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-353408","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/353408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=353408"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/353408\/revisions"}],"predecessor-version":[{"id":353409,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/353408\/revisions\/353409"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=353408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=353408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=353408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}