{"id":359158,"date":"2017-08-15T12:05:45","date_gmt":"2017-08-15T16:05:45","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/08\/170815120545.htm"},"modified":"2017-08-15T12:05:45","modified_gmt":"2017-08-15T16:05:45","slug":"how-a-nutrient-glutamine-can-control-gene-programs-in-cells","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=359158","title":{"rendered":"How a nutrient, glutamine, can control gene programs in cells"},"content":{"rendered":"<p>Researchers show that an intracellular metabolite of glutamine, alpha-ketoglutarate, plays a role in regulating cellular differentiation programs by changing the DNA-binding patterns of the transcription factor CTCF and by altering genome interactions. As an added level of gene program control complexity, they have found that the genome&#8217;s context near the binding sites &#8212; such as epigenetic changes or altered genome topology &#8212; affects whether the binding turns on or turns off gene programs. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers show that an intracellular metabolite of glutamine, alpha-ketoglutarate, plays a role in regulating cellular differentiation programs by changing the DNA-binding patterns of the transcription factor CTCF and by altering genome interactions&#8230;.<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-359158","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/359158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=359158"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/359158\/revisions"}],"predecessor-version":[{"id":359159,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/359158\/revisions\/359159"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=359158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=359158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=359158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}