{"id":362252,"date":"2017-08-21T12:27:44","date_gmt":"2017-08-21T16:27:44","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/08\/170821122744.htm"},"modified":"2017-08-21T12:27:44","modified_gmt":"2017-08-21T16:27:44","slug":"searching-for-the-signature-causes-of-brcaness-in-breast-cancer","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=362252","title":{"rendered":"Searching for the &#8216;signature&#8217; causes of BRCAness in breast cancer"},"content":{"rendered":"<p>Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature known in cancer genomics as &#8216;Signature 3.&#8217; But not all breast tumor cells exhibiting Signature 3 have BRCA1 or BRCA2 mutations. Therefore, some consider Signature 3 a biomarker for &#8216;BRCAness,&#8217; a sign of a breakdown in BRCA-related DNA repair in general and not BRCA damage in particular. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature known in cancer genomics as &#8216;Signature 3.&#8217; But not all breast tumor cells exhibiting Signature 3 have BRCA1 or BRCA2 mutations. Therefore, some &#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-362252","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/362252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=362252"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/362252\/revisions"}],"predecessor-version":[{"id":362253,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/362252\/revisions\/362253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=362252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=362252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=362252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}