{"id":385075,"date":"2017-10-06T03:44:13","date_gmt":"2017-10-06T07:44:13","guid":{"rendered":"https:\/\/ntrs.nasa.gov\/search.jsp?R=20170009163"},"modified":"2017-10-06T03:44:13","modified_gmt":"2017-10-06T07:44:13","slug":"toxicity-of-mineral-dusts-and-a-proposed-mechanism-for-the-pathogenesis-of-particle-induced-lung-diseases","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=385075","title":{"rendered":"Toxicity of Mineral Dusts and a Proposed Mechanism for the Pathogenesis of Particle-Induced Lung Diseases"},"content":{"rendered":"<p>Abstract: The mechanism of particle-induced lung pathology is still poorly understood. Neutrophilic inflammation and oxidative stress (OS) are toxicological hallmarks in the lungs of dust-exposed animals. Some investigators attribute OS-induced pathogenicity to particle surface reactivity (SR) or free radicals generated by dusts. Using 5 dusts (3 lunar dusts [LDs], quartz, and TiO2) that differed 18-fold in SR, we showed that the SRs of particles did not correlate with the dusts&#8217; toxicities in the lung&#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: The mechanism of particle-induced lung pathology is still poorly understood. Neutrophilic inflammation and oxidative stress (OS) are toxicological hallmarks in the lungs of dust-exposed animals. Some investigators attribute OS-induced pathoge&#8230;<\/p>\n","protected":false},"author":60,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-385075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/385075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/60"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=385075"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/385075\/revisions"}],"predecessor-version":[{"id":385076,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/385075\/revisions\/385076"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=385075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=385075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=385075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}