{"id":386062,"date":"2017-10-10T15:14:20","date_gmt":"2017-10-10T19:14:20","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=711839c83fc6d433198e2106f60c178c"},"modified":"2017-10-10T15:14:20","modified_gmt":"2017-10-10T19:14:20","slug":"unexpected-regulation-of-transcription-factors-critical-to-development-2","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=386062","title":{"rendered":"Unexpected regulation of transcription factors critical to development"},"content":{"rendered":"<p>A team of developmental biologists at the University of Massachusetts Amherst led by Dominique Alfandari, with others at MIT, report in a new paper that they have for the first time described how two transcription factors that are &#8220;absolutely essential for human development&#8221; are regulated by a cell surface metalloprotease known as ADAM13. The discovery adds to knowledge of how cells migrate in vertebrate embryos, how stem cells differentiate and how cancer cells metastasize.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of developmental biologists at the University of Massachusetts Amherst led by Dominique Alfandari, with others at MIT, report in a new paper that they have for the first time described how two transcription factors that are &#8220;absolutely essential&#8230;<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-386062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/386062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=386062"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/386062\/revisions"}],"predecessor-version":[{"id":386063,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/386062\/revisions\/386063"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=386062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=386062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=386062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}