{"id":388704,"date":"2017-10-16T07:38:52","date_gmt":"2017-10-16T11:38:52","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=2ef1ddbac764fb0f51d326d6a5eaced2"},"modified":"2017-10-16T07:38:52","modified_gmt":"2017-10-16T11:38:52","slug":"structural-insights-into-processes-at-dna-damage-sites","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=388704","title":{"rendered":"Structural insights into processes at DNA damage sites"},"content":{"rendered":"<p>Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites of DNA damage. They focus on the Ddc2-RPA interaction, which brings the Mec1-Ddc2 kinase complex to single-stranded DNA at sites of DNA damage. With their structural data, the FMI scientists provide the missing link between two previously published structures, allowing them to assemble a to-scale composite structural model of Mec1-Ddc2 on ssDNA-RPA at DNA damage sites.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites of DNA damage. They focus o&#8230;<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-388704","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/388704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=388704"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/388704\/revisions"}],"predecessor-version":[{"id":388705,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/388704\/revisions\/388705"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=388704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=388704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=388704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}