{"id":400790,"date":"2017-11-08T11:21:17","date_gmt":"2017-11-08T15:21:17","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/11\/171108102117.htm"},"modified":"2017-11-08T11:21:17","modified_gmt":"2017-11-08T15:21:17","slug":"early-intervention-may-hold-key-to-treatment-of-friedreichs-ataxia","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=400790","title":{"rendered":"Early intervention may hold key to treatment of Friedreich&#8217;s ataxia"},"content":{"rendered":"<p>Current treatments may be administered too late to target Friedreich&#8217;s ataxia effectively. New research using a slow-onset frataxin knock-in\/knockout mouse model showed significantly reduced levels of mitochondrial biosynthesis proteins and early mitochondrial deficiency in the cerebellar cortex, even at pre-symptomatic stages of development. This suggests that the progressive degeneration in mitochondrial function seen in individuals with Friedreich&#8217;s ataxia is not only the mechanism causing the disease, but also a potential biomarker and therapeutic target. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Current treatments may be administered too late to target Friedreich&#8217;s ataxia effectively. New research using a slow-onset frataxin knock-in\/knockout mouse model showed significantly reduced levels of mitochondrial biosynthesis proteins and early mitoc&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-400790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/400790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=400790"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/400790\/revisions"}],"predecessor-version":[{"id":400791,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/400790\/revisions\/400791"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=400790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=400790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=400790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}