{"id":402729,"date":"2017-11-13T10:55:27","date_gmt":"2017-11-13T14:55:27","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/11\/171113095527.htm"},"modified":"2017-11-13T10:55:27","modified_gmt":"2017-11-13T14:55:27","slug":"deadly-combination-in-neurodegenerative-diseases-revealed","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=402729","title":{"rendered":"Deadly combination in neurodegenerative diseases revealed"},"content":{"rendered":"<p>Aging is the key risk factor for neurodegenerative diseases, and accumulation of the protein TDP-43 in neurons is a pathological feature of frontotemporal dementia and amyotrophic lateral sclerosis. However, the specific effect of aging on the protein TDP-43 has not been investigated. Researchers have now found in mice that interneuron degeneration occurs upon aging, and TDP-43 accelerates age-dependent neuronal degeneration, which may be related to the impaired memory of TDP-43 transgenic mice. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aging is the key risk factor for neurodegenerative diseases, and accumulation of the protein TDP-43 in neurons is a pathological feature of frontotemporal dementia and amyotrophic lateral sclerosis. However, the specific effect of aging on the protein &#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-402729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/402729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=402729"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/402729\/revisions"}],"predecessor-version":[{"id":402730,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/402729\/revisions\/402730"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=402729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=402729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=402729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}