{"id":411167,"date":"2017-11-30T15:11:53","date_gmt":"2017-11-30T19:11:53","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/11\/171130141153.htm"},"modified":"2017-11-30T15:11:53","modified_gmt":"2017-11-30T19:11:53","slug":"to-proliferate-or-not-to-proliferate-a-cellular-spring-replies-3","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=411167","title":{"rendered":"To proliferate or not to proliferate? A cellular spring replies"},"content":{"rendered":"<p>The epithelium is subjected to multiple types of mechanical stretch. Researchers have discovered that the proteins ZO-1 and ZO-2, which contribute to the tightness of the epithelium, perceive these physical signals and activate cellular responses accordingly. These results reveal a novel process by which mechanical forces can regulate the structure of epithelia, their dynamic equilibrium and the establishment of tissue barriers. Targeted inhibition of ZO-1 in tumors could therefore be a pathway to explore. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>The epithelium is subjected to multiple types of mechanical stretch. Researchers have discovered that the proteins ZO-1 and ZO-2, which contribute to the tightness of the epithelium, perceive these physical signals and activate cellular responses accor&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-411167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/411167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=411167"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/411167\/revisions"}],"predecessor-version":[{"id":411168,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/411167\/revisions\/411168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=411167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=411167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=411167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}