{"id":415502,"date":"2017-12-11T16:28:25","date_gmt":"2017-12-11T20:28:25","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2017\/12\/171211152825.htm"},"modified":"2017-12-11T16:28:25","modified_gmt":"2017-12-11T20:28:25","slug":"patients-individual-genomes-may-affect-efficacy-safety-of-gene-editing-2","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=415502","title":{"rendered":"Patients&#8217; individual genomes may affect efficacy, safety of gene editing"},"content":{"rendered":"<p>Gene editing has begun to be tested in clinical trials, using CRISPR-Cas9 and other technologies to directly edit DNA inside people&#8217;s cells, and multiple trials are recruiting or in planning. A new study raises a note of caution, finding person-to-person genetic differences that may undercut the efficacy of gene editing or, more rarely, cause potentially dangerous &#8216;off target&#8217; effects. It suggests that gene editing may need to be adapted to each patient&#8217;s genome. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene editing has begun to be tested in clinical trials, using CRISPR-Cas9 and other technologies to directly edit DNA inside people&#8217;s cells, and multiple trials are recruiting or in planning. A new study raises a note of caution, finding person-to-pers&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-415502","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/415502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=415502"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/415502\/revisions"}],"predecessor-version":[{"id":415503,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/415502\/revisions\/415503"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=415502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=415502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=415502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}