{"id":458089,"date":"2018-04-02T16:06:18","date_gmt":"2018-04-02T20:06:18","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/04\/180402160618.htm"},"modified":"2018-04-02T16:06:18","modified_gmt":"2018-04-02T20:06:18","slug":"uncovering-a-mechanism-causing-chronic-graft-vs-host-disease-after-bone-marrow-transplant","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=458089","title":{"rendered":"Uncovering a mechanism causing chronic graft-vs-host disease after bone marrow transplant"},"content":{"rendered":"<p>MicroRNA-17-92 is required for the T-cell and B-cell pathogenicity that drives chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplant (BMT), report investigators. Data from cGVHD mouse models showed that, by determining T-cell and B-cell differentiation and function, miR-17-92 is responsible for cGVHD development. Inhibiting miR-17 is a potential therapeutic strategy for preventing cGVHD in BMT patients. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>MicroRNA-17-92 is required for the T-cell and B-cell pathogenicity that drives chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplant (BMT), report investigators. Data from cGVHD mouse models showed that, by determining T-cel&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-458089","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/458089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=458089"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/458089\/revisions"}],"predecessor-version":[{"id":458090,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/458089\/revisions\/458090"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=458089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=458089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=458089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}