{"id":460313,"date":"2018-04-05T09:32:11","date_gmt":"2018-04-05T13:32:11","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/04\/180405093211.htm"},"modified":"2018-04-05T09:32:11","modified_gmt":"2018-04-05T13:32:11","slug":"tolerating-yourself-a-novel-pathway-to-regulate-b-cell-activity-and-prevent-autoimmunity","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=460313","title":{"rendered":"Tolerating yourself: A novel pathway to regulate B cell activity and prevent autoimmunity"},"content":{"rendered":"<p>Autoimmune disease is an abnormal immune response to the self and is prevented by a mechanism called tolerance. Researchers have identified a pathway that regulates B cell tolerance &#8212; two proteins, GARP and TGF-beta, interact to temper B cell activity, thereby regulating autoimmunity. Monitoring GARP levels on B cells may provide a diagnostic marker for autoimmune disease, and this pathway may represent a potential future therapeutic target for treatment. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autoimmune disease is an abnormal immune response to the self and is prevented by a mechanism called tolerance. Researchers have identified a pathway that regulates B cell tolerance &#8212; two proteins, GARP and TGF-beta, interact to temper B cell activity&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-460313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/460313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=460313"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/460313\/revisions"}],"predecessor-version":[{"id":460314,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/460313\/revisions\/460314"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=460313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=460313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=460313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}