{"id":463613,"date":"2018-04-16T10:34:31","date_gmt":"2018-04-16T14:34:31","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/04\/180416103431.htm"},"modified":"2018-04-16T10:34:31","modified_gmt":"2018-04-16T14:34:31","slug":"formidable-duo-protective-effect-of-cd9-and-cd81-in-copd-and-accelerated-aging","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=463613","title":{"rendered":"Formidable duo: Protective effect of CD9 and CD81 in COPD and accelerated aging"},"content":{"rendered":"<p>Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, but the mechanism remains unclear. Researchers studied the aging-like phenotype and its underlying mechanisms in a COPD mouse model. Double deletion of tetraspanins CD9 and CD81 in epithelial cells downregulated expression of the protein SIRT. As SIRT1 is a key molecule that protects against various lifestyle-related diseases and aging, these tetraspanins may serve as novel therapeutic targets for COPD and aging. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, but the mechanism remains unclear. Researchers studied the aging-like phenotype and its underlying mechanisms in a COPD mouse model. Double deletion of tetraspanins CD&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-463613","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/463613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=463613"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/463613\/revisions"}],"predecessor-version":[{"id":463614,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/463613\/revisions\/463614"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=463613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=463613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=463613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}