{"id":465179,"date":"2018-04-19T13:24:04","date_gmt":"2018-04-19T17:24:04","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=c0518fc400ffaea5d148d0a87f360ce6"},"modified":"2018-04-19T13:24:04","modified_gmt":"2018-04-19T17:24:04","slug":"putting-proteins-in-their-proper-place","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=465179","title":{"rendered":"Putting proteins in their proper place"},"content":{"rendered":"<p>A host of special molecules called nuclear RNA-binding proteins (RBPs), when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). &#8220;Clumps that form from these disease proteins are composed of sticky fibrils that damage nerve cells,&#8221; said James Shorter, PhD, an associate professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania. &#8220;We want to reverse the formation of these clumps and put the RNA-binding proteins back in their proper place, inside the nucleus.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A host of special molecules called nuclear RNA-binding proteins (RBPs), when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). &#8220;Clump&#8230;<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-465179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/465179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=465179"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/465179\/revisions"}],"predecessor-version":[{"id":465180,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/465179\/revisions\/465180"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=465179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=465179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=465179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}