{"id":481561,"date":"2018-06-01T09:38:09","date_gmt":"2018-06-01T13:38:09","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/06\/180601093809.htm"},"modified":"2018-06-01T09:38:09","modified_gmt":"2018-06-01T13:38:09","slug":"direct-visualization-of-dynamic-structures-of-protein-disaggregation-molecular-machines-2","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=481561","title":{"rendered":"Direct visualization of dynamic structures of protein disaggregation molecular machines"},"content":{"rendered":"<p>ClpB, an ATP-fueled protein molecular machine, disentangles and reactivates aggregated proteins. By using high-speed atomic force microscopy, conformational dynamics of ClpB was visualized for the first time. ClpB forms open- and closed-ring, and the closed-ring was further classified into three forms; round, spiral, and twisted-half-spiral. These structures transformed each other during ATPase-cycle to perform protein disaggregation. This research will help to treat protein aggregations, which are related to various diseases and cause problems in industry. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>ClpB, an ATP-fueled protein molecular machine, disentangles and reactivates aggregated proteins. By using high-speed atomic force microscopy, conformational dynamics of ClpB was visualized for the first time. ClpB forms open- and closed-ring, and the c&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-481561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/481561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=481561"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/481561\/revisions"}],"predecessor-version":[{"id":481562,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/481561\/revisions\/481562"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=481561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=481561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=481561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}