{"id":481663,"date":"2018-06-01T13:48:01","date_gmt":"2018-06-01T17:48:01","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/06\/180601134801.htm"},"modified":"2018-06-01T13:48:01","modified_gmt":"2018-06-01T17:48:01","slug":"when-push-comes-to-shove-airway-cells-propel-liver-cancer-spread-to-lungs","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=481663","title":{"rendered":"When push comes to shove: Airway cells propel liver cancer spread to lungs"},"content":{"rendered":"<p>Researchers identified a crucial role for air sac-based scavenger blood cells, alveolar macrophages (AMs), in driving hepatocellular cancer metastasis in the lungs. AMs were found to be recruited by interstitial macrophages (IMs) through interactions between the IM-expressed signaling molecule CCL2 and its AM-expressed receptor. AMs then secrete leukotriene B4, which promotes tumor cell growth. This is the first evidence for the distinct roles of AMs and IMs in liver cell lung metastasis. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers identified a crucial role for air sac-based scavenger blood cells, alveolar macrophages (AMs), in driving hepatocellular cancer metastasis in the lungs. AMs were found to be recruited by interstitial macrophages (IMs) through interactions b&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-481663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/481663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=481663"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/481663\/revisions"}],"predecessor-version":[{"id":481664,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/481663\/revisions\/481664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=481663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=481663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=481663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}