{"id":495284,"date":"2018-07-09T11:00:01","date_gmt":"2018-07-09T15:00:01","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=0bf3a3dd13524b522e406644437cea0c"},"modified":"2018-07-09T11:00:01","modified_gmt":"2018-07-09T15:00:01","slug":"genome-editing-reduces-cholesterol-in-large-animal-model-laying-human-trial-groundwork","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=495284","title":{"rendered":"Genome editing reduces cholesterol in large animal model, laying human trial groundwork"},"content":{"rendered":"<p>Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, a species of monkey, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. This is the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. The team published their study this week in Nature Biotechnology, in which they describe a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors\u2014drugs that are commonly used to combat high cholesterol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, a species of monkey, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. This is the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. The team published their study this week in Nature Biotechnology, in which they describe a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors&mdash;drugs that are commonly used to combat high cholesterol.<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-495284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/495284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=495284"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/495284\/revisions"}],"predecessor-version":[{"id":495285,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/495284\/revisions\/495285"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=495284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=495284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=495284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}