{"id":495311,"date":"2018-07-09T11:11:42","date_gmt":"2018-07-09T15:11:42","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/07\/180709111142.htm"},"modified":"2018-07-09T11:11:42","modified_gmt":"2018-07-09T15:11:42","slug":"genome-editing-reduces-cholesterol-in-large-animal-model-laying-human-trial-groundwork-2","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=495311","title":{"rendered":"Genome editing reduces cholesterol in large animal model, laying human trial groundwork"},"content":{"rendered":"<p>Using genome editing to inactivate a protein called PCSK9 effectively reduced cholesterol levels in rhesus macaques. This is the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. The study describes a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors &#8212; drugs that are commonly used to combat high cholesterol. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using genome editing to inactivate a protein called PCSK9 effectively reduced cholesterol levels in rhesus macaques. This is the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. The&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-495311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/495311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=495311"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/495311\/revisions"}],"predecessor-version":[{"id":495312,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/495311\/revisions\/495312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=495311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=495311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=495311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}