{"id":505161,"date":"2018-08-06T15:20:13","date_gmt":"2018-08-06T19:20:13","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/08\/180806152013.htm"},"modified":"2018-08-06T15:20:13","modified_gmt":"2018-08-06T19:20:13","slug":"doxorubicin-disrupts-the-immune-system-to-cause-heart-toxicity","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=505161","title":{"rendered":"Doxorubicin disrupts the immune system to cause heart toxicity"},"content":{"rendered":"<p>Doxorubicin is a chemotherapy drug used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. Researchers have found an important contributor to that heart pathology &#8212; disruption of the metabolism that controls immune responses in the spleen and heart. This dysregulated immunometabolism impairs resolution of inflammation, and chronic, non-resolving inflammation leads to advanced heart failure. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Doxorubicin is a chemotherapy drug used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. Researchers have found an i&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-505161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/505161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=505161"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/505161\/revisions"}],"predecessor-version":[{"id":505162,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/505161\/revisions\/505162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=505161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=505161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=505161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}