{"id":514777,"date":"2018-08-29T08:13:29","date_gmt":"2018-08-29T12:13:29","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/08\/180829081329.htm"},"modified":"2018-08-29T08:13:29","modified_gmt":"2018-08-29T12:13:29","slug":"ketamine-activates-opioid-system-to-treat-depression","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=514777","title":{"rendered":"Ketamine activates opioid system to treat depression"},"content":{"rendered":"<p>A new study finds that ketamine&#8217;s acute antidepressant effect requires opioid system activation, the first time that a receptor site has been shown in humans to be necessary for any antidepressant&#8217;s mechanism of action. While opioids have been used historically to treat depression, they are known to carry a high risk of dependence. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study finds that ketamine&#8217;s acute antidepressant effect requires opioid system activation, the first time that a receptor site has been shown in humans to be necessary for any antidepressant&#8217;s mechanism of action. While opioids have been used his&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-514777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/514777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=514777"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/514777\/revisions"}],"predecessor-version":[{"id":514778,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/514777\/revisions\/514778"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=514777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=514777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=514777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}