{"id":542946,"date":"2018-11-05T13:24:38","date_gmt":"2018-11-05T17:24:38","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/11\/181105122438.htm"},"modified":"2018-11-05T13:24:38","modified_gmt":"2018-11-05T17:24:38","slug":"drug-design-clues-for-drugging-the-undruggable","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=542946","title":{"rendered":"Drug design: Clues for drugging the &#8216;undruggable&#8217;"},"content":{"rendered":"<p>Scientists have shown how thalidomide analogs mediate degradation of many more proteins than previously anticipated. These proteins &#8212; zinc finger transcription factors &#8212; play a role in cancer and developmental diseases but are difficult drug targets. The new study suggests that thalidomide analogs can be rationally designed to target this challenging class of proteins. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have shown how thalidomide analogs mediate degradation of many more proteins than previously anticipated. These proteins &#8212; zinc finger transcription factors &#8212; play a role in cancer and developmental diseases but are difficult drug targets&#8230;.<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-542946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/542946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=542946"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/542946\/revisions"}],"predecessor-version":[{"id":542947,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/542946\/revisions\/542947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=542946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=542946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=542946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}