{"id":547854,"date":"2018-11-16T17:45:08","date_gmt":"2018-11-16T21:45:08","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/11\/181116164508.htm"},"modified":"2018-11-16T17:45:08","modified_gmt":"2018-11-16T21:45:08","slug":"from-the-ashes-of-a-failed-pain-drug-a-new-therapeutic-path-emerges","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=547854","title":{"rendered":"From the ashes of a failed pain drug, a new therapeutic path emerges"},"content":{"rendered":"<p>A surprising discovery about a failed pain drug &#8212; and specifically, the pathway it targets, BH4 &#8212; could have implications for autoimmunity and cancer. Neuroscientists report that BH4 also functions as a kind of immunological thermostat, raising and lowering the activity levels of T cells. Inhibiting BH4 could relieve atopic dermatitis, psoriasis, lupus, polyarthritis and inflammatory bowel disease; boosting it could help the immune system attack cancers. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A surprising discovery about a failed pain drug &#8212; and specifically, the pathway it targets, BH4 &#8212; could have implications for autoimmunity and cancer. Neuroscientists report that BH4 also functions as a kind of immunological thermostat, raising and l&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-547854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/547854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=547854"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/547854\/revisions"}],"predecessor-version":[{"id":547855,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/547854\/revisions\/547855"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=547854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=547854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=547854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}