{"id":552914,"date":"2018-11-27T04:50:41","date_gmt":"2018-11-27T08:50:41","guid":{"rendered":"https:\/\/ntrs.nasa.gov\/search.jsp?R=20180007539"},"modified":"2018-11-27T04:50:41","modified_gmt":"2018-11-27T08:50:41","slug":"cdkn1ap21-plays-a-critical-role-in-suppressing-stem-cell-regenerative-potential-during-aging","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=552914","title":{"rendered":"CDKN1a\/p21 Plays a Critical Role in Suppressing Stem Cell Regenerative Potential During Aging"},"content":{"rendered":"<p>Abstract: Unloading during spaceflight is known to adversely affect mammalian physiology. Mechanical stimulation is required for repair and regeneration by stem cell lineages to maintain tissue health and mass. CDKN1a\/p21 functions as a potent cell cycle arrest molecule and we previously found that CDKN1a\/p21 was overexpressed in mouse bone during 15-days of spaceflight on STS-131 and localized to osteoprecursor cells in the femur. Therefore, we hypothesized that altered expression of CDKN1a\/p21 leads &#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: Unloading during spaceflight is known to adversely affect mammalian physiology. Mechanical stimulation is required for repair and regeneration by stem cell lineages to maintain tissue health and mass. CDKN1a\/p21 functions as a potent cell cyc&#8230;<\/p>\n","protected":false},"author":60,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-552914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/552914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/60"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=552914"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/552914\/revisions"}],"predecessor-version":[{"id":552915,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/552914\/revisions\/552915"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=552914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=552914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=552914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}