{"id":562115,"date":"2018-12-27T11:21:09","date_gmt":"2018-12-27T15:21:09","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2018\/12\/181227102109.htm"},"modified":"2018-12-27T11:21:09","modified_gmt":"2018-12-27T15:21:09","slug":"long-term-memory-encoding-engram-neurons-are-established-by-the-transcriptional-cycling","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=562115","title":{"rendered":"Long-term memory encoding engram neurons are established by the transcriptional cycling"},"content":{"rendered":"<p>Long-term memory (LTM) is formed by repetitive training trials with rest intervals and LTM formation requires transcription factors, including CREB and c-Fos. Researchers found that ERK activity is increased during rest intervals to induce transcriptional cycling between c-Fos and CREB in a subset of mushroom body neurons. Significantly, LTM is encoded in these mushroom body neurons, and blocking outputs from these neurons suppress recall of LTM whereas activating these neurons produces memory-associated behaviors. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Long-term memory (LTM) is formed by repetitive training trials with rest intervals and LTM formation requires transcription factors, including CREB and c-Fos. Researchers found that ERK activity is increased during rest intervals to induce transcriptio&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-562115","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/562115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=562115"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/562115\/revisions"}],"predecessor-version":[{"id":562116,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/562115\/revisions\/562116"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=562115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=562115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=562115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}