{"id":570989,"date":"2019-01-23T14:17:03","date_gmt":"2019-01-23T18:17:03","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2019\/01\/190123131703.htm"},"modified":"2019-01-23T14:17:03","modified_gmt":"2019-01-23T18:17:03","slug":"small-metabolites-have-big-effects-on-the-intestinal-immune-response","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=570989","title":{"rendered":"Small metabolites have big effects on the intestinal immune response"},"content":{"rendered":"<p>Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause CX3CR1+ macrophages in the intestine to protrude their tentacle-like dendrites to capture antigens, triggering the immune response, was unclear. Now, a research team has shown that common bacterial metabolites pyruvate and lactate interact with the GPR31 receptor on CX3CR1+ cells, enhancing the immune response and protecting against gut pathogens. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause CX3CR1+ macrophages in the intestine to protrude their tentacle-like dendrites to capture antigens,&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-570989","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/570989","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=570989"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/570989\/revisions"}],"predecessor-version":[{"id":570990,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/570989\/revisions\/570990"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=570989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=570989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=570989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}