{"id":574414,"date":"2019-02-01T11:55:11","date_gmt":"2019-02-01T15:55:11","guid":{"rendered":"https:\/\/spaceweekly.com\/?guid=30732956cec4a835cefb3189d07d154b"},"modified":"2019-02-01T11:55:11","modified_gmt":"2019-02-01T15:55:11","slug":"directed-evolution-of-a-designer-enzyme-with-an-unnatural-catalytic-amino-acid-2","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=574414","title":{"rendered":"Directed evolution of a designer enzyme with an unnatural catalytic amino acid"},"content":{"rendered":"<p>The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists have now demonstrated that such fine-tuning is also possible for &#8220;designer&#8221; enzymes with unnatural catalytic amino acids. In the journal Angewandte Chemie, they report that laboratory &#8220;evolution&#8221; of a designer enzyme with an aniline side chain led to variants with significantly higher activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists have now demonstrated that&#8230;<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-574414","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/574414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=574414"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/574414\/revisions"}],"predecessor-version":[{"id":574415,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/574414\/revisions\/574415"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=574414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=574414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=574414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}