{"id":595415,"date":"2019-03-21T13:03:30","date_gmt":"2019-03-21T17:03:30","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2019\/03\/190321130330.htm"},"modified":"2019-03-21T13:03:30","modified_gmt":"2019-03-21T17:03:30","slug":"how-sleeper-cell-cancer-stem-cells-are-maintained-in-chronic-myelogenous-leukemia","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=595415","title":{"rendered":"How &#8216;sleeper cell&#8217; cancer stem cells are maintained in chronic myelogenous leukemia"},"content":{"rendered":"<p>Even when chronic myelogenous leukemia is in remission, &#8216;sleeper cell,&#8217; quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression of a particular chemokine by a particular type of bone marrow cell controls quiescence of these treatment-resistant leukemic stem cells. The chemokine is CXCL12, and the particular bone marrow cells expressing it are mesenchymal stromal cells. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Even when chronic myelogenous leukemia is in remission, &#8216;sleeper cell,&#8217; quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression &#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-595415","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/595415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=595415"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/595415\/revisions"}],"predecessor-version":[{"id":595416,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/595415\/revisions\/595416"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=595415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=595415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=595415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}