{"id":605796,"date":"2019-04-11T10:18:32","date_gmt":"2019-04-11T14:18:32","guid":{"rendered":"https:\/\/www.sciencedaily.com\/releases\/2019\/04\/190411101832.htm"},"modified":"2019-04-11T10:18:32","modified_gmt":"2019-04-11T14:18:32","slug":"loss-of-a-dna-repair-system-creates-a-unique-vulnerability-in-many-cancer-types","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=605796","title":{"rendered":"Loss of a DNA repair system creates a unique vulnerability in many cancer types"},"content":{"rendered":"<p>Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes&#8217; activity, in the process becoming dependent on those genes for their survival and growth. The resulting genetic dependencies may provide targets for developing new precision-guided drugs or other cancer treatment strategies. Reporting in Nature, researchers describe one such vulnerability shared by a large subset of colon, gastric, endometrial, and ovarian cancer cell lines. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes&#8217; activity, in the process becoming dependent on those genes for their survival and growth. The resulting genetic dependencies may pr&#8230;<\/p>\n","protected":false},"author":61,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-605796","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/605796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=605796"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/605796\/revisions"}],"predecessor-version":[{"id":605797,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/605796\/revisions\/605797"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=605796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=605796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=605796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}