{"id":608445,"date":"2019-04-18T11:00:02","date_gmt":"2019-04-18T15:00:02","guid":{"rendered":"http:\/\/spaceweekly.com\/?guid=4381a29a05064ea4bc3d88930b9a1df8"},"modified":"2019-04-18T11:00:02","modified_gmt":"2019-04-18T15:00:02","slug":"studies-identify-mechanism-key-to-removal-of-protein-aggregates-from-cells","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=608445","title":{"rendered":"Studies identify mechanism key to removal of protein aggregates from cells"},"content":{"rendered":"<p>Massachusetts General Hospital (MGH) investigators have discovered the mechanism by which cells sense dysfunction of the proteasome\u2014a cellular component that degrades unneeded or defective proteins\u2014and respond in a previously undescribed manner, by editing the amino acid sequence of a key sensing protein. Proteasome dysfunction can lead to the type of buildup of aberrant proteins that characterizes neurodegenerative disorders such as Alzheimer&#8217;s disease and is also seen in normal aging. The report is being published in the journal Cell.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Massachusetts General Hospital (MGH) investigators have discovered the mechanism by which cells sense dysfunction of the proteasome&mdash;a cellular component that degrades unneeded or defective proteins&mdash;and respond in a previously undescribed manner, by editing the amino acid sequence of a key sensing protein. Proteasome dysfunction can lead to the type of buildup of aberrant proteins that characterizes neurodegenerative disorders such as Alzheimer&#8217;s disease and is also seen in normal aging. The report is being published in the journal Cell.<\/p>\n","protected":false},"author":0,"featured_media":615444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-608445","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/608445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=608445"}],"version-history":[{"count":1,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/608445\/revisions"}],"predecessor-version":[{"id":608446,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/608445\/revisions\/608446"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=608445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=608445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=608445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}