{"id":622897,"date":"2019-07-05T10:15:59","date_gmt":"2019-07-05T14:15:59","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=622897"},"modified":"2019-07-05T10:15:59","modified_gmt":"2019-07-05T14:15:59","slug":"programmed-cell-death-the-roles-of-caspase-1-and-gasdermin-d-in-apoptosis-and-pyroptosis","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=622897","title":{"rendered":"Programmed cell death: The roles of caspase-1 and gasdermin D in apoptosis and pyroptosis"},"content":{"rendered":"<p>Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa University and others discovered that caspase-1 proteolytically activates Bid and initiates apoptosis in GSDMD-deficient cells. Furthermore, cortical neurons and mast cells, exhibiting little GSDMD expression, undergo apoptosis after appropriate stimulation in a caspase-1- and Bid-dependent manner. This study clarifies molecular mechanisms and biological roles of caspase-1-induced apoptosis in GSDMD-low\/null cells.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2019-07-cell-death-roles-caspase-gasdermin.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Programmed cell death: The roles of caspase-1 and gasdermin D in apoptosis and pyroptosis<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa University and others discovered that caspase-1 proteolytically activates&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-622897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/622897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=622897"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/622897\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=622897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=622897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=622897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}