{"id":637092,"date":"2019-11-11T09:29:11","date_gmt":"2019-11-11T13:29:11","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=637092"},"modified":"2019-11-11T09:29:11","modified_gmt":"2019-11-11T13:29:11","slug":"dna-sos-understanding-dna-signaling-pathways","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=637092","title":{"rendered":"DNA SOS: Understanding DNA signaling pathways"},"content":{"rendered":"<p>When cells suffer DNA damage, they send out an SOS signal. When the repair crew arrives, the emergency signal is cancelled as it is no longer needed. This two-stage process is an important one in many different diseases, but the underlying mechanisms are not well understood. ADP-ribosylation is one of the DNA damage response mechanisms used by cells to send out an SOS signal; and the ARH family of enzymes is involved in canceling the signal. In work recently published in Cell Chemical Biology, researchers from the University of Oxford&#8217;s DNA Damage Response Lab investigated the structure of two ADP-(ribosyl)hydrolases (ARHs). Their results provide important insights into the differences between these two proteins and offer useful tools for targeted drug design.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2019-11-dna-sos-pathways.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">DNA SOS: Understanding DNA signaling pathways<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When cells suffer DNA damage, they send out an SOS signal. When the repair crew arrives, the emergency signal is cancelled as it is no longer needed. This two-stage process&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-637092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/637092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=637092"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/637092\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=637092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=637092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=637092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}