{"id":660330,"date":"2020-07-09T10:51:51","date_gmt":"2020-07-09T14:51:51","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=660330"},"modified":"2020-07-09T10:51:51","modified_gmt":"2020-07-09T14:51:51","slug":"optn-atg9-interaction-accelerates-autophagic-degradation-of-ubiquitin-labeled-mitochondria","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=660330","title":{"rendered":"OPTN-ATG9 interaction accelerates autophagic degradation of ubiquitin-labeled mitochondria"},"content":{"rendered":"<p>Researchers at TMIMS have revealed that PINK1 (a serine\/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria to induce selective autophagy called mitophagy. Dysfunction of this type of mitophagy causes a decrease in mitochondrial quality and an overproduction of ROS, and thus is linked to the development of hereditary recessive Parkinson&#8217;s disease.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2020-07-optn-atg9-interaction-autophagic-degradation-ubiquitin-labeled.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">OPTN-ATG9 interaction accelerates autophagic degradation of ubiquitin-labeled mitochondria<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at TMIMS have revealed that PINK1 (a serine\/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria to induce&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-660330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/660330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=660330"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/660330\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=660330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=660330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=660330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}