{"id":680871,"date":"2021-02-11T10:30:01","date_gmt":"2021-02-11T14:30:01","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=680871"},"modified":"2021-02-11T10:30:01","modified_gmt":"2021-02-11T14:30:01","slug":"iridium-catalyzed-z-retentive-asymmetric-allylic-substitution-reactions","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=680871","title":{"rendered":"Iridium-catalyzed Z-retentive asymmetric allylic substitution reactions"},"content":{"rendered":"<p>In synthetic organic chemistry, Z-olefins are a challenging synthetic target to produce in the lab due to their relative thermodynamic instability. The Z-olefins form an unsaturated compound with a CnH2n formula that can be readily isomerized. Analogous reactions used to synthesize optically active Z-olefin products are rare. In a new report now published on Science, Ru Jiang and a research team at the University of Chinese Academy of Sciences in Shanghai, China, detailed an iridium-catalyzed asymmetric allylic substitution reaction to retain Z-olefin geometries while establishing an adjacent quaternary stereocenter. The team observed the formation of transient anti-\u03c0-allyl-iridium intermediates and their capture by external nucleophiles (electron donor) before isomerization to form thermodynamically more stable syn-\u03c0-allyl-iridium counterparts. The results provide a promising method to prepare chiral Z-olefin compounds in the lab.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2021-02-iridium-catalyzed-z-retentive-asymmetric-allylic-substitution.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Iridium-catalyzed Z-retentive asymmetric allylic substitution reactions<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In synthetic organic chemistry, Z-olefins are a challenging synthetic target to produce in the lab due to their relative thermodynamic instability. The Z-olefins form an unsaturated compound with a CnH2n&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-680871","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/680871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=680871"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/680871\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=680871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=680871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=680871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}