{"id":715867,"date":"2022-02-08T08:30:54","date_gmt":"2022-02-08T12:30:54","guid":{"rendered":"https:\/\/spaceweekly.com\/?p=715867"},"modified":"2022-02-08T08:30:54","modified_gmt":"2022-02-08T12:30:54","slug":"one-step-strategy-to-synthesize-site-specific-antibody-drug-conjugates-with-lacnac-based-substrates","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=715867","title":{"rendered":"One-step strategy to synthesize site-specific antibody-drug conjugates with LacNAc-based substrates"},"content":{"rendered":"<p>Antibody-drug conjugates (ADCs), a complex covalently linking a potent cytotoxin onto the antibody, has attracted great interest as a novel biotherapeutic approach. Site-specific conjugation of potent payloads can improve the therapeutic index of ADCs compared with random conjugation. Glycosite-specific ADCs (gsADCs), harnessing Asn297 N-glycan of IgG Fc as the conjugation site for drug payloads, usually require multi-steps for IgG glycoengineering with two or more enzymes, thus limiting the substrates diversification and complicating the preparation process.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2022-02-one-step-strategy-site-specific-antibody-drug-conjugates.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">One-step strategy to synthesize site-specific antibody-drug conjugates with LacNAc-based substrates<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibody-drug conjugates (ADCs), a complex covalently linking a potent cytotoxin onto the antibody, has attracted great interest as a novel biotherapeutic approach. Site-specific conjugation of potent payloads can improve the&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-715867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/715867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=715867"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/715867\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=715867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=715867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=715867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}