{"id":717864,"date":"2022-02-28T12:44:22","date_gmt":"2022-02-28T16:44:22","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=717864"},"modified":"2022-02-28T12:44:22","modified_gmt":"2022-02-28T16:44:22","slug":"how-a-two-faced-molecule-can-silence-problematic-genes","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=717864","title":{"rendered":"How a two-faced molecule can silence problematic genes"},"content":{"rendered":"<p>Researchers have developed a technology, heteroduplex oligonucleotide (HDO), that silences certain genes whose high expression levels fuel disease. Adding a specific molecular tag allowed them to target the HDO to immune cells called lymphocytes safely and efficiently. Doing so with an HDO specific to a gene called Itga4 improved symptoms in a mouse model of multiple sclerosis, suggesting this technology may be developed to use in human immune disorders.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/www.sciencedaily.com\/releases\/2022\/02\/220228114422.htm\" target=\"_blank\" rel=\"nofollow noopener\">How a two-faced molecule can silence problematic genes<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: ScienceDaily&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have developed a technology, heteroduplex oligonucleotide (HDO), that silences certain genes whose high expression levels fuel disease. Adding a specific molecular tag allowed them to target the HDO to&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-717864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genaero"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/717864","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=717864"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/717864\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=717864"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=717864"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=717864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}