{"id":718684,"date":"2022-03-08T11:57:39","date_gmt":"2022-03-08T15:57:39","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=718684"},"modified":"2022-03-08T11:57:39","modified_gmt":"2022-03-08T15:57:39","slug":"a-new-analysis-method-to-identify-interacting-proteins-in-the-development-of-drugs","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=718684","title":{"rendered":"A new analysis method to identify interacting proteins in the development of drugs"},"content":{"rendered":"<p>Protein degraders, which induce the protein degradation of target proteins, are expected to be the &#8220;next-generation drugs&#8221; because they can remove disease-related proteins from cells. Protein degraders, such as thalidomide and its derivatives (Immunomodulatory drugs\/IMiDs), induce the degradation of specific proteins by binding to cereblon (CRBN), which is a component of the E3 ubiquitin ligase complex, a proteolytic enzyme. IMiDs function as a &#8220;molecular glue&#8221;, inducing protein degradation by recruiting target proteins to E3 ubiquitin ligase and are called molecular glue-type proteolytic inducers.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2022-03-analysis-method-interacting-proteins-drugs.html\" target=\"_blank\" rel=\"nofollow noopener\">A new analysis method to identify interacting proteins in the development of drugs<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Protein degraders, which induce the protein degradation of target proteins, are expected to be the &#8220;next-generation drugs&#8221; because they can remove disease-related proteins from cells. Protein degraders, such as thalidomide&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-718684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/718684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=718684"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/718684\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=718684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=718684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=718684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}