{"id":720552,"date":"2022-04-06T14:06:43","date_gmt":"2022-04-06T18:06:43","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=720552"},"modified":"2022-04-06T14:06:43","modified_gmt":"2022-04-06T18:06:43","slug":"inspiration-and-thinking-in-the-design-of-large-scale-functional-proteins-evolution-guided-atomistic-design","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=720552","title":{"rendered":"Inspiration and thinking in the design of large-scale functional proteins: Evolution-guided atomistic design"},"content":{"rendered":"<p>On 08 March 2022, the journal\u00a0BioDesign Research published a review\u00a0article titled &#8220;What Have We Learned from Design of Function in Large Proteins?&#8221;\u00a0by Olga Khersonsky and Sarel J. Fleishman. The article proposes an evolution-guided atomistic design approach\u00a0that eliminates mutations that could destabilize proteins, induce misfolding, or distort the active site domain of residues, and preserves non-ideal key sequences and structural features through the use of natural backbone and sequence constraints.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2022-04-large-scale-functional-proteins-evolution-guided-atomistic.html\" target=\"_blank\" rel=\"nofollow noopener\">Inspiration and thinking in the design of large-scale functional proteins: Evolution-guided atomistic design<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>On 08 March 2022, the journal\u00a0BioDesign Research published a review\u00a0article titled &#8220;What Have We Learned from Design of Function in Large Proteins?&#8221;\u00a0by Olga Khersonsky and Sarel J. Fleishman. The article&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-720552","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/720552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=720552"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/720552\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=720552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=720552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=720552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}