{"id":730045,"date":"2022-07-19T08:48:29","date_gmt":"2022-07-19T12:48:29","guid":{"rendered":"https:\/\/spaceweekly.com\/?p=730045"},"modified":"2022-07-19T08:48:29","modified_gmt":"2022-07-19T12:48:29","slug":"scientists-identify-cell-fate-regulatory-programs-using-single-cell-atlas-of-mouse-development","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=730045","title":{"rendered":"Scientists identify cell-fate regulatory programs using single-cell atlas of mouse development"},"content":{"rendered":"<p>The robustness of the developmental process for multicellular organisms suggests a dedicated regulatory program that governs the trajectories of cell-fate decisions. According to Waddington&#8217;s epigenetic landscape theory, differentiated cell types arise from an unstable stem\/progenitor state and eventually fall into stable cell-fate attractors. The emerging concept of the state manifold derived from single-cell data has further enhanced our understanding of lineage progression. What are the gene-regulatory programs underlying these state manifolds? How are they regulated? These two questions remain enigmatic in this field.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2022-07-scientists-cell-fate-regulatory-single-cell-atlas.html\" target=\"_blank\" rel=\"nofollow noopener\">Scientists identify cell-fate regulatory programs using single-cell atlas of mouse development<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The robustness of the developmental process for multicellular organisms suggests a dedicated regulatory program that governs the trajectories of cell-fate decisions. According to Waddington&#8217;s epigenetic landscape theory, differentiated cell types&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-730045","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/730045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=730045"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/730045\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=730045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=730045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=730045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}